Michael D. Weston, MA, PhD
School of Dentistry
- Oral Biology
- Assistant Professor
- Cerutis,DR, Weston MD, Alnouti Y, Bathena SP, Nunn ME, Ogunleye AO, McVaney TP, Headen KV, Miyamoto T. A major human oral lysophosphatidic acid species, LPA 18:1, regulates novel genes in human gingival fibroblasts., J Periodontol, 86(5), 713-25, 2015
- Tarang, S., Weston, M. D. Macros in microRNA target identification: A comparative analysis of in silico, in vitro, and in vivo approaches to microRNA target identification, RNA Biology, 11, 324-333, 2014
- Cerutis,DR, Weston MD, Ogunleye AO, McVaney TP, Miyamoto T. Lysophosphatidic acid (LPA) 18:1 transcriptional regulation of primary human gingival fibroblasts., Genomics Data, Vol. 2, 375-376, 2014
- Rocha-Sanchez SM, Scheetz LR, Siddiqi S, Weston MW, Smith LM, Dempsy K, Ali H. McGee J, Walsh E. Lack of Rbl1/p107 effects on cell proliferation and maturation in the inner ear., Ear. J Behav Brain Sci, 3(7), 534-555, 2013
- Grati, M., Shin, J. B., Weston, M. D., Green, J., Bhat, M. A., Gillespie, P. G., Kachar, B. Localization of PDZD7 to the Stereocilia Ankle-Link Associates this Scaffolding Protein with the Usher Syndrome Protein Network, Journal of neuroscience : the official journal of the Society for Neuroscience, 32, 14288-14293, 2012
- Grati M. Shin JB, Weston MD, Green J, Bhat MA, Gillespie PG, Kachar B. Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network., Maternal Child Nursing, 32(41), 14288-14293, 2012
- Rocha-Sanchez, S. M., Scheetz, L. R., Contreras, M., Weston, M. D., Korte, M., McGee, J., Walsh, E. J. Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells, Journal of Neuroscience, 31, 8883-8893, 2011
- Weston, M. D., Pierce, M. L., Jensen-Smith, H. C., Fritzsch, B., Rocha-Sanchez, S., Beisel, K. W., Soukup, G. A. MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival, Developmental Dynamics, 240, 95-99, 2011
- Rocha-Sanchez SM, Scheetz L, Contreras M, Weston MD, Korte M, McGee J, Walsh E. Mature Mice Lacking Rbl2/p130 Gene Have Supernumerary Inner Ear Hair Cells and Supporting Cells., J Neurosci, 31(24), 8883-93, 2011
- Weston MD, Pierce ML, Jensen-Smith HC, Fritzsch B, Rocha-Sanchez S, Beisel KW, Soukup GA. MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival., Dev Dyn, 240(4), 808-19, 2011
- Pierce, M. L., Weston, M. D., Fritzsch, B., Gabel, H. W., Ruvkun, G., Soukup, G. A. MicroRNA-183 family conservation and ciliated neurosensory organ expression, Evolution & Development, 10, 106-113, 2008
Grant Funding Received
- Weston (PI) CURAS Faculty Research Fund 06/01/2015 – 05/31/16 Creighton University Center for Undergraduate Research and Scholarship. Project Title: Periostin’s role in dental tissue homeostasis. The goal of the research is to identify Periostin as a key modulatory protein of inflammation to maintain periodontal ligament homeostasis and function. Role: Project PI. - $2,000 / 1 year
- LB692 Weston (PI) 07/01/14 – 06/30/15 Nebraska Tobacco Settlement Biomedical Research Development New Initiative Grant Project Title: miRNA and RNAi effects on hair cell transdifferentiation by ATOH1. The goal of the proposed research is to generate direct evidence that miRNA post-transcriptional gene regulation promotes postnatal HC transdifferentiation. Role: Project PI – 75,000 / 1 year.
- P20 RR017717 Smith (PI) 06/01/09 – 05/30/13 NIH/NCRR, Molecular biology of neurosensory systems Project Title: Project 11 Characterization of a MicroRNA misexpression model of age related deafness. The goal of this project is to identify the mechanism of Tg-miRNA mediated hair cell loss that should generate new knowledge relevant to inner ear homeostasis of therapeutic value to treat hearing loss disease. Role: Project PI – 170,000 / year.
- R03 DC010453 Weston (PI) 12/01/0 – 11/30/12 NIH/NIDCD Project Title:. A mouse model of deafness caused by microRNA misexpression. Ideas on the causes of human age related hearing loss (presbycusis) are dominated by defects in mechanisms intrinsic to neurosensory cells (i.e ganglion, hair cells), due to the fact that many mouse deafness models have sensory cell defects. This mouse model suggests hair cell death is significantly influenced through a degradation of supporting cell function. Identifying the mechanism of Tg-miRNA mediated hair cell loss should generate new knowledge relevant to inner ear homeostasis of therapeutic relevance to hearing loss disease.
- Weston, M (PI) Rocha- Sanchez, SM (Co-PI)/ NIH/ Academic Research Enhancement Award (Parent R15) (Federal). Dates: 9/01/2015 – 8/31/2018 436,500